Hello there, I’m Firas Hammami. I have recently finished my PhD in Bioinformatics and Genomics at Aix-Marseille Université under the supervision of Elisabeth Remy (Institut de Mathématiques de Marseille, I2M) and Pierre Mandin (Laboratoire de Chimie Bactérienne, LCB).
I’m interested in the mathematical modelling approach (especially the logic formalism) and its application on biological systems, such as the regulation of the Iron Sulfur Cluster biogenesis in the bacterium Escherichia coli. The mathematical modelling approach allows me to better understand the complex regulations involved in biological processes, which i’m fond of!
On this website, you will see that I got passionnate about two more things: teaching and making videos. By the way, I was a founder of a collaboration for Bioinfuse (a french contest for the popularization of Bioinformatics), which won the 2017 edition.
PhD in Bioinformatics and Genomics, 2019
MSc in Bioinformatics, Structural Biology and Genomics, 2015
MSc in Life Sciences, 2014
Université de Nice Sophia Antipolis
Sony Vegas / After Effects / Inkscape / GIMP
GINsim / MaBoSS
Molecular Biology / Microbiology
Subject: Statistics for biologists (96h Courses/Tutorials/Practicals)
Used the logical modelling approach to understand Iron-Sulfur cluster biogenesis regulation depending of the environment (Iron/Oxygen) in Escherichia coli. A full description of the PhD thesis will be available soon.
Courses given during my PhD:
Summary Members of the wnt gene family encode secreted glycoproteins that mediate critical intercellular communications in metazoans. Large-scale genome and transcriptome analyses have shown that this family is composed of 13 distinct subfamilies. These analyses have further established that the number of wnt genes per subfamily varies significantly between metazoan phyla, highlighting that gene duplication and gene loss events have shaped the complements of wnt genes during evolution. In sea urchins, for example, previous work reported the absence of representatives of both the WNT2 and WNT11 subfamilies in two different species, Paracentrotus lividus and Strongylocentrotus purpuratus. Recently, however, we identified a gene encoding a WNT2 ortholog in P. lividus and, based on that finding, we also reanalyzed the genome of S. purpuratus. Yet, we found no evidence of a bona fide wnt2 gene in S. purpuratus. Furthermore, we established that the P. lividus wnt2 gene is selectively expressed in vegetal tissues during embryogenesis, in a pattern that is similar, although not identical, to that of other P. lividus wnt genes. Taken together, this study amends previous work on the P. lividus wnt complement and reveals an unexpected variation in the number of wnt genes between closely related sea urchin species.